TABLE 2.
Determination of specific enzyme activities of wild-type LsNit, RsNit, and SmNit and mutants
| Enzyme activity toward substrates (U · mg−1) |
||||||||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | |
| Nitrilase |
|
|
|
|
|
|
|
|
| LsNit | 24.69 | 5.80 | 7.06 | 7.88 | 64.47 | 24.09 | 159.73 | 26.70 |
| Ls-W165G-V193L | 164.02 | 50.87 | 54.42 | 9.01 | 16.57 | 11.40 | 12.73 | 7.38 |
| RsNit | 9.97 | 1.02 | 0.27 | 0.13 | 0.22 | 0.0065 | 0.00075 | 0.00016 |
| Rs-W164G-V192L | 64.29 | 21.13 | 8.66 | 0.49 | 0.049 | 0.00085 | 0.000027 | 0 |
| SmNit | 1.91 | 0 | 0 | 0 | 1.88 | 0 | 5.75 | 0 |
| Sm-W184G-V212L | 7.14 | 1.23 | 0.88 | 0 | 0.80 | 0 | 0.91 | 0 |