Table 2.

Summary table of tools available to support researchers in planning and reporting reproducible animal research.

Tool or guideline	Year	Purpose	Description
EQIPD quality system (Bespalov et al. 2021)	2021	All phases	A set of 18 essential recommendations aiming to improve the reproducibility and reliability of preclinical research.https://quality-preclinical-data.eu/about-eqipd/eqipd-quality-system/
The Experimental Design Assistant (Percie du Sert et al. 2017)	2017	Planning	The EDA is an online platform facilitating researchers to plan animal experiments, get feedback on their study design, and download a schematic diagram, which can be used to visualise their study design and improve reproducibility and transparency. This resource aims to help improve internal validity and animal welfare alongside reducing bias and research waste. https://eda.nc3rs.org.uk/
The PREPARE guidelines (Smith et al. 2018)	2018	Planning	15-item checklist aiming to improve the planning of animal research, embedding reproducibility from the very beginning. PREPARE covers three broad areas which they claim are often missing from other reporting guidelines: (i) formulation of the study, (ii) dialogues between scientists and the animal facility, and (iii) methods, including health monitoring, housing and husbandry, and humane killing, release, reuse, or rehoming. https://norecopa.no/prepare
The ARRIVE guidelines (Percie du Sert et al. 2020)	2010 (updated in 2020)	Reporting	A checklist of 10 ‘essential’ and 11 ‘recommended’ items, aiming to improve reproducibility, transparency, and animal welfare. Endorsed by over 1000 journals. https://arriveguidelines.org/
Gold Standard Publication Checklist (GSPC) (Hooijmans et al. 2010)	2010	Reporting	An extensive checklist aiming to improve transparency and animal welfare in preclinical studies. https://doi.org/10.1177/026119291003800208
The MDAR Checklist (Macleod et al. 2021)	2021	Reporting	18-item checklist designed to help authors comply with the MDAR (Materials, Design, Analysis, and Reporting) Framework, which may be endorsed by journals. The MDAR Framework aims to improve transparency in four key areas of life sciences research: Materials, Design, Analysis, and Reporting. https://osf.io/bj3mu/