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. 2023 Jun 5;11(6):507. doi: 10.3390/toxics11060507

Table 7.

Urinary cypermethrin metabolites (GM(GSD), nmole/g creatinine) of conventional farmers, classified by age, sex, insecticide use at home in the past 1 year, cypermethrin use on their farm, and the use of insecticides at home (Aswin, Ars, Baygon, Shieldtox, and the mosquito coil) did not report taking a bath immediately after spraying, kept all used chemical containers at home for disposal, and had a daily intake of vegetables.

3-PBA Cis-DCCA Trans-DCCA Cis,trans-DCCA Total Cypermethrin
GM (GSD) p-Value GM (GSD) p-Value GM (GSD) p-Value GM (GSD) p-Value GM (GSD) p-Value
Age 1
1. <35 4.14 (3.30) 0.287 12.07 (2.50) 0.090 6.82 (2.52) 0.016,
(1–2) p = 0.013,
(1–3)
p = 0.046
20.16 (2.26) 0.053,
(1–2) p = 0.042
24.94 (2.33) 0.056,
2. 35–60 6.33 (3.25) 18.76 (2.41) 11.84 (2.41) 31.74 (2.31) 39.45 (2.33) (1–2) p = 0.044
3. >60 6.09 (3.58) 18.22 (2.57) 11.88 (2.13) 30.96 (2.29) 38.15 (2.38)
Sex 2
Male 5.67 (3.41) 0.241 16.35 (2.50) 0.022 * 10.87 (2.47) 0.477 28.46 (2.36) 0.112 35.32 (2.40) 0.119
Female 7.08 (3.02) 22.61 (2.25) 12.00 (2.22) 35.18 (2.19) 43.63 (2.20)
Insecticide use at home in the past 1 year 2
Yes 5.89 (3.33) 0.480 18.11 (2.26) 0.389 11.21 (2.37) 0.791 30.43 (2.29) 0.544 37.46 (2.33) 0.831
No 7.13 (3.26) 15.21 (2.84) 10.63 (2.73) 27.11 (2.66) 35.94 (2.64)
Cypermethrin use on the farm 2
Yes 9.77 (2.66) <0.001 * 24.37 (2.28) <0.001 * 12.76 (2.39) 0.040 * 37.82 (2.25) <0.001 * 48.52 (2.33) <0.001 *
No 3.97 (3.38) 13.60 (2.41) 9.94 (2.38) 24.74 (2.27) 29.83 (2.30)
Type of insecticide used at home
ARS 2,3
Yes 9.24 (2.54) 0.052 25.31 (2.18) 0.043 * 12.46 (2.27) 0.515 38.02 (2.18) 0.151 48.04 (2.17) 0.123
No 5.58 (3.45) 17.22 (2.44) 11.02 (2.41) 29.41 (2.31) 36.20 (2.36)
Baygon 2,3
Yes 8.03 (2.93) <0.001 * 21.02 (2.46) 0.008 * 12.54 (2.36) 0.043 * 34.74 (2.29) 0.012 * 43.83 (2.31) 0.004 *
No 4.05 (3.57) 14.92 (2.30) 9.67 (2.40) 25.59 (2.25) 30.75 (2.30)
Shieldtox 2,3
Yes 5.89 (3.61) 0.958 17.12 (2.46) 0.734 11.63 (2.49) 0.816 29.98 (2.34) 0.924 36.94 (2.42) 0.914
No 5.98 (3.33) 18.27 (2.43) 11.14 (2.38) 30.49 (2.30) 37.68 (2.34)
Mosquito coil 2,3
Yes 6.09 (3.29) 0.662 18.69 (2.43) 0.358 11.61 (2.37) 0.289 31.57 (2.29) 0.245 38.86 (2.32) 0.307
No 5.54 (3.64) 16.18 (2.41) 9.89 (2.46) 26.61 (2.33) 33.31 (2.43)
Did not take a bath immediately after spraying 2
Yes 11.12 (2.20) <0.001 * 25.32 (2.25) <0.001 * 13.69 (2.32) 0.014 * 40.07 (2.18) <0.001 * 52.01 (2.15) <0.001 *
No 4.34 (3.49) 14.77 (2.44) 10.01 (2.41) 25.85 (2.31) 31.32 (2.35)
Kept all used chemical containers at home for disposal 2
Yes 9.25 (2.48) <0.001 * 22.44 (2.27) <0.001 * 12.34 (2.30) 0.092 35.41 (2.22) 0.005 * 45.42 (2.22) <0.001 *
No 3.88 (3.66) 14.06 (2.52) 10.06 (2.49) 25.49 (2.36) 30.57 (2.40)
Daily vegetable intake 2
Yes 7.25 (3.04) 0.007 * 20.28 (2.47) 0.013 * 12.40 (2.39) 0.039 * 34.16 (2.30) 0.010 * 42.65 (2.32) 0.008 *
No 4.63 (3.56) 14.84 (2.39) 9.63 (2.38) 25.22 (2.28) 31.02 (2.33)

1 Multiple comparisons with the Tukey scores on the natural logs of metabolite concentration; p-value refers to the overall ANOVA and p-value of each subgroup; 2 t-test on the natural logs of metabolite concentration. 3 Main ingredients of insecticide used at home. ARS sprays contain imiprothrin 0.2%, cypermethrin 0.1% [21]. Baygon sprays contain cypermethrin (0.1%) and other pyrethroids, imiprotin (0.03%), and prallethrin (0.03%) [22]. Shieldtox sprays contain other pyrethroids, prallethrin 0.076%, and D-phenothrin 0.046% [23]. Mosquito coils have different brands with different active ingredients, but the main active ingredients are also pyrethroids, dimefluthrin, allethrin, metofluthrin, etc. [24,25]. * Significant at a p-value < 0.05.