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Decrease of plasma glucose concentration (%) in diabetic rats upon administration of subcutaneous insulin, 2.5 UI/kg (empty squares); oral insulin solution, 25 IU/kg (empty triangles); insulin-loaded SLNs, 25 IU/kg (filled squares); and insulin-loaded chitosan-coated SLN, 25 IU/Kg (filled circles). N = 6; mean ± SEM. Reprinted with permission from [115].
