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Extraglandular manifestations in pSS. Abbreviation: RP, Raynaud phenomenon; CVL, cutaneous vasculitis lesions; CNS, central nervous system; PNS, peripheral nervous system; ANS, autonomic nervous system; RTA, renal tubular acidosis; GN, glomerulonephritis; ILD, interstitial lung disease; MR- MCNT, inhibit muscarinic receptor-mediated cholinergic neurotransmission; TIA, transient ischemic attacks; PH, pulmonary hypertension; CAVB, congenital atrioventricular block. ↓, low; ↑, high.
