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Table 2.

SDH subunit fragility based on SIFT.

SDH subunit (L)a Aligned positionsb (P) Positions tolerating four or fewer substitutions (S) Fraction (P/S)
A (622) 475 246 0.52
B (252) 187 106 0.57
C (140) 100 38 0.38
D (103) 93 49 0.53

Bold indicates greatest value in column.

aMature subunit length in amino acids; bNumber of amino acid positions with SIFT alignment score of 1.0.