Table 1.

Overview of the variant types of TNDM including the affected gene focus and localisation.

Type of congenital diabetes	Affected gene	Localisation	Frequency
TNDM 1	PLAGL1 and HYMAI genes	Associated with aberrations in chromosomal region 6q24.	70%
TNDM 2	Activating, autosomal, dominantly inherited mutations in the ABCC8 gene	Chromosome 11	N/a
TNDM 3	Activating, autosomal,dominantly inherited mutations in the KCNJ11 gene	Chromosome 11	N/a