Figure 1.

Pharmacokinetics and biodistribution after TL-532 administration in mice. TL-532 pharmacokinetics were evaluated in 12 male swiss mice by i.P. (a), i.V. bolus (b) and s.C. (c) injection at the following concentrations of 5 mg/kg, 2 mg/kg, and 10 mg/kg, respectively. Biodistribution of Cyanine-5 conjugated TL-532 injected intravenously in four BALB/c-nude mice bearing MBT2 tumors was performed using quantitative fluorescent molecular tomography (d and e). Global quantifications over time are shown for the whole-body, liver, tumor and draining lymph-nodes (d), and expressed relatively to the organ weight for both liver and the tumor (e).