Table 3.
Cytotoxic activities of sesquiterpene coumarins isolated from the roots of Ferula huber-morathii.
| Compounds | IC50 (µM) a | |||
|---|---|---|---|---|
| COLO 205 | K-562 | MCF-7 | HUVEC | |
| Conferone (1) | 27.63 ± 0.69 | 55.50 ± 0.94 | 34.02 ± 0.68 | 46.12 ± 0.99 |
| Conferol (2) | 11.19 ± 0.68 | 35.23 ± 0.89 | 15.95 ± 0.46 | 61.03±0.29 |
| Feselol (3) | 38.41 ± 0.80 | 72.48 ± 0.74 | 35.95 ± 1.29 | 38.75 ± 0.83 |
| Badrakemone (4) | >200 | >200 | >200 | >200 |
| Mogoltadone (5) | 31.71 ± 0.15 | 21.11 ± 0.85 | 30.45 ± 0.60 | >200 |
| Farnesiferol A (6) | >200 | >200 | >200 | 74.43 ± 1.19 |
| Farnesiferol A acetate (7) | 66.03 ± 1.89 | 52.71 ± 0.90 | 27.40 ± 0.96 | 64.53 ± 1.56 |
| Gummosin (8) | >200 | 95.53 ± 4.87 | >200 | 174.78 ± 0.28 |
| Ferukrin (9) | >200 | >200 | 81.69 ± 1.96 | >200 |
| Ferukrin acetate (10) | 105.72 ± 1.35 | 88.42 ± 0.85 | >200 | >200 |
| Deacetylkellerin (11) | >200 | >200 | 47.62 ± 0.40 | >200 |
| Kellerin (12) | 51.05 ± 1.57 | 78.14± 3.13 | 18.24 ± 0.12 | 99.39 ±1.63 |
| Samarcandone (13) | 125.14 ± 2.13 | >200 | >200 | 190.44 ± 5.20 |
| Samarcandin (14) | 170.03 ± 3.62 | 143.03 ± 1.67 | 83.27 ± 0.39 | 169.16 ± 2.68 |
| Samarcandin acetate (15) | 70.29 ± 0.65 | 78.67 ± 1.65 | >200 | >200 |
| Cisplatin b | 111.87 ± 3.11 | 8.10 ± 0.25 | 64.22 ± 5.25 | 40.68 ± 1.12 |
| Doxorubicin c | 0.08 ± 0.00 | 0.33 ± 0.02 | 2.83 ± 0.25 | 0.20 ± 0.02 |
a 50% inhibitory concentrations in COLO 205, K-562, MCF-7, and HUVEC cells in the test assay. Values are the means ± standard deviations obtained for at least three independent experiments. b,c Positive controls.