Table 1.
List of licensed type of adjuvant and aluminum content of aluminum-adjuvanted vaccines for use in the United States (Information accessed on FDA website on 5 May 2023 (https://www.fda.gov/vaccines-blood-biologics/vaccines/vaccines-licensed-use-united-states, accessed on 5 May 2023)).
| Adjuvant | Vaccine | Tradename | Manufacturer | Dose (Al3+) |
|---|---|---|---|---|
| AH | Anthrax | BioThrax® | Emergent Biosolutions | 1.2 mg |
| AH | Infanrix® | GSK | ≤0.625 mg | |
| AH | DTaP, polio | Kinrix® | GSK | ≤0.6 mg |
| AH | DTaP, Hepatitis B, polio | Pediarix® | GSK | ≤0.85 mg |
| AH | Hepatitis A | Havrix® | GSK | 0.5 mg (adult) 0.25 mg (pediatric) |
| AH | Hepatitis B | Engerix | GSK | 0.5 mg (adult) 0.25 mg (pediatric) |
| AH | PREHEVBRIO® | VBI | 0.5 mg | |
| AH | Human papilloma virus | Cervarix® | GSK | 0.5 mg (plus 50 µg MPLA) |
| AH | Meningococcus B | Bexsero® | GSK | 0.519 mg |
| AH | Boostrix® | GSK | ≤0.39 mg | |
| AH | Tick-Borne Encephalitis | TICOVAC® | Pfizer | 0.35 mg (adult) 0.175 mg (pediatric) |
| AH | Japanese Encephalitis | IXIARO® | Valneva Austria GmbH | 0.25 mg |
| AH and AP | Hepatitis A and Hepatitis B | Twinrix® | GSK | 0.45 mg |
| AP | Diphtheria and Tetanus Toxoids Adsorbed | / | Sanofi-Pasteur | 0.33 mg |
| AP | / | Sanofi-Pasteur | 0.33 mg | |
| AP | Tenivac® | MassBiologics | ≤0.53 mg | |
| AP | TDVAX® | MassBiologics | ≤0.53 mg | |
| AP | DTaP | Daptacel® | Sanofi-Pasteur | 0.33 mg |
| AP | Adacel® | Sanofi-Pasteur | 0.33 mg | |
| AP | DTaP, polio | Quadracel® | Sanofi-Pasteur | 0.33 mg |
| AP | DTaP, polio, Hib | Pentacel® | Sanofi-Pasteur | 0.33 mg |
| AP | DTaP, polio, Hib, Hepatitis B | VAXELIS® | MSP | 0.319 mg |
| AP | Meningococcus B | Trumenba® | Pfizer | 0.25 mg |
| AP | Meningococcus B | TRUMENBA® | Wyeth | 0.25 mg |
| AP | Pneumococcus 13-valent Conjugate | Prevnar 13® | Pfizer | 0.125 mg |
| AP | Pneumococcal 15-valent Conjugate | VAXNEUVANCE® | Merck | 0.125 mg |
| AP | Pneumococcal 20-valent Conjugate | PREVNAR 20® | Pfizer | 0.125 mg |
| AAHS | Hib | PedVaxHIB® | Merck | 0.225 mg |
| AAHS | Hepatitis A | VAQTA® | Merck | 0.45 mg (adult) 0.225 mg (pediatric) |
| AAHS | Hepatitis B | Recombivax HB® | Merck | 0.5 mg (adult) 0.25 mg (pediatric) |
| AAHS | Human papilloma virus | Gardasil® | Merck | 0.225 mg |
| AAHS | Human papilloma virus | Gardasil-9® | Merck | 0.5 mg |
AH: aluminum hydroxide adjuvant; AP: aluminum phosphate adjuvant; AAHS: amorphous aluminum hydroxyphosphate sulfate; DTaP: diphtheria toxoid, tetanus toxoid, acellular pertussis; Hib: Haemophilus influenza B.