Figure 1.

The phylogenetic tree of EV-D68 clinical isolates selected for cloning. Full-length genome sequences were analyzed. The numbers next to each tree branch represent bootstrap values showing the percentage of replicate trees that the viral strain clustered together. The branch lengths represent the evolutionary distance in units of base pair differences per viral sequence, with the scale bar denoting difference. Severity of symptoms designations: As—asymptomatic; Ex—exacerbation; M—mild; S—severe; numbers following the designations indicate symptom score where available. Filled and empty circles of the same color show symptomatic and asymptomatic infections, respectively.