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. Author manuscript; available in PMC: 2024 Apr 25.
Published in final edited form as: Chemistry. 2023 Feb 13;29(24):e202300138. doi: 10.1002/chem.202300138

Figure 1.

Figure 1.

Dioxygen (O2) transport in PHF8. (A) Dioxygen (O2) transport in PHF8 via tunnel-1 obtained from diffusion dynamics. The tunnel residues are not labeled here for clarity but are shown in detail in Figures S5–S7. (B) The approach of dioxygen to the Fe(II)-center for likely formation of an in-line Fe(III)-OO−. complex following 2OG rearrangement. (C) The dioxygen approach for likely formation of an off-line Fe(III)-OO−. complex. The Fe(II)-center, dioxygen, 2OG, and H3K9me2 substrates are shown as balls and sticks.