Table 1.
Clinical characteristics of probands at recruitment along with the genes having pathogenic variants
| Code no. | Sex | DTP dose | Vaccine type | Age at first seizure in months | Age at enrolment in months | Seizure semiology | Seizure duration range in minutes | Clustering | Number of seizures in infancy | Diagnosis | Gene with pathogenic variant |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | F | 3rd | DTwP | 5.5 | 40 | GC | >30 | Yes | >10 | Dravet Syndrome | ·· |
| 2 | M | 3rd | DTwP | 4.5 | 96 | GC | 5–14 | No | >10 | Dravet Syndrome | SCN1A |
| 3 | M | 3rd | DTwP | 6 | 59 | GC | 15–30 | No | >10 | Dravet Syndrome | SCN1A |
| 4 | M | 3rd | DTwP-HepB-HiB | 4 | 14 | GC | <5 | Yes | 0–4 | Complex febrile seizure | ·· |
| 5 | M | 1st | DTwP | 1.5 | 71 | GC | <5 | No | >10 | Dravet Syndrome | SCN1A |
| 6 | M | 3rd | DTwP | 4 | 5 | ES | <5 | Yes | >10 | West syndrome | ·· |
| 7 | M | 3rd | DTwP | 3.5 | 41 | GC | <5 | Yes | 0–4 | Simple febrile seizure | ·· |
| 8 | F | 3rd | DTwP | 4 | 21 | FIAM | >30 | No | >10 | Dravet Syndrome | SCN1A |
| 9 | M | 2nd | DTwP-HepB-HiB | 3 | 56 | GC | <5 | Yes | >10 | Self-limited myoclonic epilepsy in infancy | ·· |
| 10 | M | 2nd | DTwP-HepB-HiB | 3.5 | 11 | FIANM | <5 | Yes | >10 | Febrile seizure plus | ·· |
| 11 | M | 2nd | DTwP | 3 | 159 | FIAM | <5 | No | >10 | Dravet Syndrome | SCN1A |
| 12 | M | 2nd | DTwP-HepB-HiB | 4 | 12 | GT | <5 | Yes | 0–4 | Complex febrile seizure | ·· |
| 13 | F | 1st | DTwP | 2 | 36 | ES | <5 | Yes | >10 | West syndrome | CDKL5 |
| 14 | F | 1st booster | DTwP | 26 | 49 | FIANM | <5 | Yes | 0–4 | Doose syndrome | ·· |
| 15 | F | 2nd | DTwP | 3 | 94 | FIAM | 5–14 | Yes | 5–10 | Dravet Syndrome | SCN1A |
| 16 | M | 2nd | DTwP | 3 | 47 | GC | 5–14 | Yes | >10 | Dravet Syndrome | SCN1A |
| 17 | M | 2nd | DTwP | 4 | 48 | FIAM | >30 | No | >10 | Dravet Syndrome | SCN1A |
| 18 | M | 2nd | DTwP | 4 | 90 | GC | >30 | Yes | >10 | Dravet Syndrome | SCN1A |
| 19 | M | 2nd | DTwP | 4.5 | 62 | GC | 5–14 | No | >10 | Dravet Syndrome | SCN1A |
| 20 | F | 3rd | DTwP | 5 | 148 | GC | <5 | No | >10 | Dravet Syndrome | SCN1A |
| 21 | F | 2nd | DTwP | 3 | 126 | FIAM | 15–30 | No | 5–10 | Dravet Syndrome | SCN1A |
| 22 | M | 1st | DTwP | 2 | 15 | FIAM | 5–14 | No | >10 | Dravet Syndrome | SCN1A |
| 23 | M | 3rd | DTwP | 5 | 5 | GC | 15–30 | Yes | 5–10 | Complex febrile seizure | ·· |
| 24 | F | 2nd | DTwP | 3 | 39 | GTC | <5 | Yes | >10 | Dravet Syndrome | SCN1A |
| 25 | F | 1st | DTwP | 1.5 | 1.5 | FIANM | <5 | No | 0–4 | Complex febrile seizure | ·· |
| 26 | M | 3rd | DTwP | 6 | 71 | GC | 5–14 | No | >10 | Dravet Syndrome | SCN1A |
| 27 | F | 3rd | DTwP-HepB-HiB | 4 | 4 | GC | <5 | Yes | 0–4 | Complex febrile seizure | KCNQ2 |
| 28 | M | 3rd | DTwP | 5 | 123 | GC | 15–30 | No | 5–10 | Dravet Syndrome | SCN8A |
| 29 | M | 1st booster | DTwP | 16 | 16 | GC | >30 | No | 0–4 | Complex febrile seizure | ·· |
| 30 | M | 1st | DTwP-HepB-HiB | 1.5 | 1.5 | FIANM | <5 | No | 0–4 | Simple febrile seizure | ·· |
| 31 | M | 1st booster | DTwP | 18 | 66 | GC | >30 | Yes | 0–4 | Complex febrile seizure | ·· |
| 32 | M | 3rd | DTwP | 4.5 | 207 | GC | <5 | No | 0–4 | Dravet Syndrome | SCN1A |
| 33 | F | 3rd | DTwP-HepB-HiB | 3.5 | 8 | GC | <5 | No | >10 | Intractable Childhood epilepsy with GTCs | ·· |
| 34 | F | 1st booster | DTwP | 18 | 29 | GTC | 5–14 | No | 0–4 | Simple febrile seizure | DEPDC5 |
| 35 | M | 1st booster | DTwP | 18 | 71 | GT | 5–14 | No | 0–4 | Complex febrile seizure | ·· |
| 36 | F | 2nd | DTwP-HepB-HiB | 3.5 | 59 | GT | <5 | No | 0–4 | Febrile seizure plus | NPRL3 |
| 37 | M | 1st booster | DTwP | 20 | 26 | GC | 5–14 | No | 0–4 | Complex febrile seizure | ·· |
| 38 | F | 1st booster | DTwP-HepB-HiB, MMR | 15 | 17 | GC | 5–14 | No | 0–4 | Simple febrile seizure | PCDH19 |
| 39 | M | 3rd | DTwP | 7 | 90 | GC | 15–30 | No | >10 | Complex febrile seizure | SCN1A |
| 40 | M | 3rd | DTwP | 6 | 7 | GC | <5 | No | 0–4 | Febrile seizure plus | ·· |
| 41 | M | 1st | DTwP-HepB-HiB | 1.5 | 2 | GT | <5 | No | 0–4 | Simple febrile seizure | RHOBTB2 |
| 42 | M | 2nd booster | DTwP | 54 | 59 | GTC | <5 | No | 0–4 | Simple febrile seizure | ·· |
| 43 | F | 3rd | DTwP | 4 | 4 | GTC | 5–14 | No | 5–10 | Complex febrile seizure | SCN1A |
| 44 | F | 2nd | DTwP-HepB-HiB | 3 | 3 | GT | 5–14 | Yes | 0–4 | Complex febrile seizure | ·· |
| 45 | F | 2nd | DTwP | 2.5 | 3 | GT | <5 | Yes | 0–4 | Complex febrile seizure | KCNA2 |
| 46 | F | 1st | DTwP | 1.5 | 7 | ES | <5 | Yes | >10 | West syndrome | GNAO1 |
| 47 | M | 3rd | DTwP | 4 | 36 | FIAM | >30 | No | >10 | Dravet Syndrome | SCN1A |
| 48 | M | 2nd | DTwP | 2.5 | 5 | GT | 5–14 | Yes | >10 | Dravet Syndrome | SCN8A |
| 49 | F | 1st | DTwP | 1.5 | 20 | FIAM | 15–30 | Yes | 5–10 | Dravet Syndrome | ·· |
| 50 | M | 3rd | DTwP | 3 | 9 | FIAM | 15–30 | No | >10 | Dravet Syndrome | SCN1A |
| 51 | M | 3rd | DTwP | 3.5 | 154 | GC | 15–30 | No | 0–4 | Febrile seizure plus | SLC2A1 |
| 52 | M | 1st booster | DTwP | 18 | 43 | GTC | 5–14 | No | 0–4 | Simple febrile seizure | ·· |
| 53 | F | 3rd | DTwP-HepB | 3 | 48 | GC | 5–14 | Yes | 5–10 | Dravet Syndrome | SCN1A |
| 54 | F | 1st | DTwP | 1.5 | 1.5 | FIANM | >30 | No | >10 | Complex febrile seizure | KCNT1 |
ES = Epileptic spasms, F = Female, FIANM = Focal impaired awareness non motor, FIAM = Focal impaired awareness motor GC = Generalized clonic, GT = Generalized tonic, GTC = Generalized tonic-clonic, M = Male.