Table 3.
Association of phenotypic characteristics with genetic diagnosis
| Characteristics | Children with genetic diagnosis (n = 33) | Children without genetic diagnosis (n = 21) | P-value | Odds ratio, 95% CI |
|---|---|---|---|---|
| Median age at vaccine-seizure in months (Q1,Q3) | 3.5 (2.75, 4.5) | 4 (3.25, 18) | 0.07 | ·· |
| Characteristics of Vaccine-proximate seizures | ||||
| • Focal onseta | 9 | 5 | >0.99 | 1.2, 95% CI: 0.4–4.1 |
| • Clustering | 10 | 12 | 0.09 | 0.3, 95% CI: 0.1–1.0 |
| • Seizure duration ≥15 min | 11 | 5 | 0.55 | 1.6, 95% CI: 0.4–5.1 |
| ≥5 seizures in infancyb | 24 | 7 | 0.006 | 5.3, 95% CI: 1.6–18.4 |
| Drug-resistance epilepsy | 23 | 4 | 0.001 | 9.8, 95% CI: 2.6–30.7 |
| Neurodevelopment impairment (SQ < 70) | 21 | 5 | 0.006 | 5.6, 95% CI: 1.65–17.6 |
a
Three children with unknown onset of epileptic spasms (two with genetic diagnosis and one without genetic diagnosis) were excluded from the analysis.
b
Based on total number of seizures during one year of follow-up for children with febrile seizures.