Fig. 1.
Xenograft tumor of PDOX in the mouse brain. (A, B) Images illustrating intra-cerebral (IC) and intra-cerebellar (ICb) and intra-brain stem (IBs) injections of pediatric brain tumor cells in the brains of SCID mice. 1 × 105 brain tumor cells was injected into SCID mouse within 60 min of tumor resection into cerebellum, cerebrum or brain stem to establish the medulloblastoma (MB), glioblastoma (GBM), ependymoma (EPN), diffuse intrinsic pontine glioma (DIPG), Atypical Teratoid Rhabdoid Tumor (ATRT) and primitive neuroectodermal tumor (PNET) models. (C) Gross appearance of H&E-stained mouse brain with huge xenograft tumors.