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. Author manuscript; available in PMC: 2024 Jul 1.
Published in final edited form as: J Psychiatr Res. 2023 May 26;163:357–364. doi: 10.1016/j.jpsychires.2023.05.069

Table 4.

Adjusted mean difference in change in serum BDNF (in ng/mL) over 2 years comparing treatment agents to their matching placebos (n=288).

Treatment groups Adjusted mean difference (95% CI)a P-value
Vitamin D3 vs. placebo 0.51 (−0.59 to 1.60) 0.36
Omega-3s vs. placebo −0.62 (−1.71 to 0.48) 0.27

Abbreviation: BDNF, brain-derived neurotrophic factor; CI, confidence interval.

a

Results from the repeated measures response profile model show mean differences in the change in serum BDNF over 2 years comparing treatment agents and placebos, after controlling for age, sex, and concurrent randomization group; all participants contributed to the repeated measure analysis at one and/or both time points.