Figure 2.

Clinical presentations according to the types of ICIs and cancer. Bar chart indicating the number of patients according to the types of cancer and ICI for each clinical phenotype. Anti-CTLA4 immunotherapy was more frequent in patients with polyradiculoneuropathy or meningitis, and less frequent in patients with myositis and/or MG, or limbic encephalitis. Conversely, melanoma was more frequent in meningitis patients, and lung cancer was more frequent in limbic encephalitis patients. Cancers other than melanoma, lung and urological cancer included thymoma (n = 4), Hodgkin lymphoma (n = 3), colorectal adenocarcinoma (n = 3), skin squamous cell carcinoma (n = 3), prostate adenocarcinoma (n = 2), Merkel carcinoma (n = 2), oropharynx squamous cell carcinoma (n = 1), breast adenocarcinoma (n = 1), pleural mesothelioma (n = 1), chordoma (n = 1), ovary carcinoma (n = 1), leiomyosarcoma (n = 1), acute myeloblastic leukaemia (n = 1), liposarcoma (n = 1) and hepatocellular carcinoma (n = 1). Abbreviations: PRN = polyradiculoneuropathy; NMJ = neuromuscular junction.