Skip to main content
. Author manuscript; available in PMC: 2023 Jun 28.
Published in final edited form as: J Med Chem. 2013 Apr 8;56(8):3235–3246. doi: 10.1021/jm301735k

Table 3.

Antiviral activity of the thiophenyl ring dichloro and trichloro analogsa

graphic file with name nihms-466361-t0017.jpg

compd R2 R6 R7 R2’ R3’ R4’ R5’ IC50
20 CO2H Me H Cl H Cl H 37
21 CO2H Me H H Cl Cl H 34
22 CO2H H Me H Cl Cl H 35
23 CO2H Et H H Cl Cl H 42
24 CO2H Me H H Cl H Cl 7
25 CO2H Et H H Cl H Cl 9
26 CO2H H H H Cl H Cl 43
27 CO2Me Me H H Cl H Cl NA
28 CONHMe Me H H Cl H Cl NA
29 CO2Me Me H H H H H 10

graphic file with name nihms-466361-t0018.jpg

compd R4 R5 R6 R7 R2’ R4’ R5’ IC50
30 H H Me H Cl Cl Cl 25
30a H H H Me Cl Cl Cl 21
30b Me H H H Cl Cl Cl 18
31 H H Me H NO2 CF3 H NA
a

IC50 values were determined from triplicate measurements and repeated at least twice. Values ≥ 100 µM were designated as not active (NA).