Table 4.

Structure-activity relationships of compound 24 analogs^a

compd	R	IC50 (nM)	cLogP		LipE	CC50 (µM)	SI
24		7000	5.5	−0.3		75	11
24a		42	5.1	2.3		16	374
24b		46	4.7	2.7		26	570
24c		208	5.6	1.1		NA	nd
24d		244	5.6	1.0		36	152
24e		NA	5.5	nd		27	nd

^aAntiviral IC₅₀ and cytotoxicity CC₅₀ values were determined from triplicate measurements and repeated at least twice. Values ≥ 100 µM were deemed not active (NA), or otherwise not determined (nd).