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. 2023 May 16;194(1):84–100. doi: 10.1093/toxsci/kfad046

Figure 2.

Figure 2.

BPF exposure effects on the thyroid in ACI males. A, At 13 weeks-of-age, thyroid glands were harvested, weighed, and adjusted for body weight. BPF-exposed ACI males had significantly increased thyroid gland tissue compared with vehicle ACI males. B, Gene expression of the TSH receptor (Tshr), important thyroid nuclear transcription factors (Nkx2-1, Pax8), thyroglobulin (Tg), thyroid peroxidase (Tpo), and critical transporters (Slc5a5, Slc26a4) (n = 9–12 per exposure group). Slc26a4 had a possible increase in expression in the BPF-exposed ACI males compared with vehicle ACI males. Unpaired, two-tailed t test with or without Welch’s correction used when appropriate for comparing vehicle and BPF-exposed ACI males only. Two-way ANOVA, Šídák’s multiple comparisons test, #p < .05.