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. 2023 Apr 10;33(4):e13159. doi: 10.1111/bpa.13159

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© 2023 The Authors. Brain Pathology published by John Wiley & Sons Ltd on behalf of International Society of Neuropathology.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Pathology semi‐quantitative rating protocol: Panels show representative examples of the five pathology density semi‐quantitative scores: (A) score 0 = no visible pathology, (B) score 1 = isolated neuronal cytoplasmic inclusions (NCIs) and/or NFT‐like structures, almost no NTs, (C) score 2 = NCIs and/or NFT‐like structures greater in number and more closely packed than score 1; NTs present in isolated patches, (D) score 3 = moderate amount of densely packed, band‐like NCIs and/or NFT‐like structures, (E) score 4 = severe pathology burden, numerous closely packed NCIs and NFT‐like structures; NTs typically densely packed throughout the layer II region with neuritic plaques. The semi‐quantitative scheme used to assess visual pTDP‐43 pathology density implemented the same density criteria from the protocol for p‐tau applied in [32]. NCI, neuronal cytoplasmic inclusion; NFT, neurofibrillary tangle; NT, neuropil threads. Magnification bar = 500 𝜇m.