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. 2022 Dec 29;33(4):e13142. doi: 10.1111/bpa.13142

FIGURE 3.

FIGURE 3

Localization of NLRP3 in microglia. Immunoreactivity of NLRP3 in the CA1 (A and D) and CA2 (B and E) hippocampal regions in a representative section of low (A–C) and in an intermediate AD (D–F) case. Expression of NLRP3 is seen mainly in the processes of the ramified microglia of low AD (A, Ai and B, Bi). The expression of NLPR3 (green) is confirmed by the confocal photomicrographs, imaged in the CA2 hippocampal region (C), where there is expression in the microglia (red; Cii) and not in the neurons (white; Ciii). Whereas, in the intermediate AD the expression densely stains the processes of activated amoeboid‐like microglia (D, Di and E, Ei). The prominent expression of NRLP3, is demonstrated in the CA2 hippocampal region (green, F and Fi) in the microglia cells (red, Fii), but absent in the neurons (Fiii). Alzheimer's disease (AD); NOD‐like receptor proteins (NLRP); Cornu Ammonis Field 2 (CA2); Cornu Ammonis Field 1 (CA1); images A, B, D, and E; scale bars = 60 μm; insert scale bars = 30 μm.