Extended Data Fig. 2. RNA-seq analysis of microglia from plasma injected brains.

a-d, Volcano plots of DEGs from RNA-seq analysis of sorted microglia from plasma or aCSF injected brains. Comparisons between DEGs in microglia from Alb^–/– plasma vs aCSF (a), C3^–/– plasma vs aCSF (b), Alb^–/– plasma vs WT plasma (c) or C3^–/– plasma vs WT plasma (d) injected brains are shown. Dots depict average log₂FC and -log₁₀ adjusted P values (abs(log₂ > 0.5, adjusted P value < 0.1 with Wald test followed by Benjamini-Hochberg multiple test correction). Data are from n = 6 Fga^–/–, n = 6 WT, n = 6 aCSF, n = 8 Alb^–/– mice.