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. 2023 Jun 8;24(7):1173–1187. doi: 10.1038/s41590-023-01522-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Top, Co-expression gene network of 196 DEGs upregulated in microglia by WT plasma compared to aCSF control. Bottom, overlay of blood gene network with microglial gene expression values from Fga^–/– plasma-treated mice. Red shading, genes upregulated in microglia; blue shading, genes downregulated in microglia; the orange boarder indicates significance of P < 0.1 (Wald test following by Benjamini-Hochberg multiple test correction). Data are from n = 3 biological replicates per group, with two mice pooled per replicate.