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. 2023 Jun 8;24(7):1173–1187. doi: 10.1038/s41590-023-01522-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — a, Violin plots of gene counts, UMI counts, and %mito for each biologically independent sample. F, female; M, male. b, Violin plots of cell type marker genes used to annotate each cluster. c, Cluster ratio per biological replicate. d, UMAP plot of all single CD11b+ cells identified by clustering analysis (n = 9,286 cells from brains of three 5XFAD, three NTG, four 5XFAD:Fgg^γ390-396A, and four Fgg^γ390-396A mice). e, UMAP plots of microglial cells subclustering analysis split by genotype. Ven diagrams depict percentage of cells per cluster.