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. 2023 Jun 7;618(7967):1085–1093. doi: 10.1038/s41586-023-06169-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Orthogonal views of the PCO371–PTH1R–G_s complex, constructed from the cryo-EM potential map and coloured according to the subunit. Violet, PCO371-bound PTH1R; magenta, PCO371; yellow, mini-Gα_s Ras-like domain; tomato, Gβ₁; navy, Gγ₂; powder blue, Nb35. b, Density map and constructed model of PCO371 near the PCO371-binding pocket. c, Close-up view of the PCO371-binding site. Numerical superscripts indicate relative positions in the receptor according to the Wootten class B1 GPCR numbering of the receptor TMD region³³. The map is shown in the 2.085 e A^–3 counter level. d, Chemical structure of PCO371. PCO371 is composed of four chemical groups (shown from left to right): trifluoromethoxyphenyl, spiro-imidazolone, dimethylphenyl and DMH.