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. 2023 Jun 7;618(7967):1085–1093. doi: 10.1038/s41586-023-06169-3

Extended Data Fig. 11. Proposed strategy for a G-protein subtype specific or bitopic agonist.

Extended Data Fig. 11

(a) TMD structures of PCO371–PTH1R–Gs are shown parallel to the membrane. (b, c) Cross-section and magnified views of the TMD. The white dashed circle shows an intracellular ligand binding pocket comprising TM1, TM7, and Helix8 (left panel). The white dashed line shows the distance between Cβ of Cys7.60 and O6 of PCO371. (d) Sequence alignment of the C-terminal region after TM7. The red box shows C4627.60 of PTH1R.