Extended Data Fig. 11. Mitotic clustering underlies distinct patterns of rearrangements following chromothripsis in micronuclei.

CIP2A-TOPBP1-mediated mitotic clustering of pulverized chromosomes from micronuclei facilitates balanced rearrangements in one of the daughter cells following mother cell division. In the absence of CIP2A-TOPBP1, pulverized fragments disperse throughout the mitotic cytoplasm and stochastically partition into both daughter cells.