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. 2023 Jun 21;618(7967):1057–1064. doi: 10.1038/s41586-023-06228-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a, Venn diagram of the overlap between the sets of transcripts that are reduced in RNA abundance or translational efficiency upon fertilization (MII-oocyte to the zygote transition). b, The mean poly(A) tail length and translation efficiency was calculated using data from 2-cell stage embryos (n = 3 Ribo-ITP; n = 4 RNA-Seq; see Methods). The boxes correspond to interquartile range and the horizontal lines indicate the median. c, Mean translation efficiency and its 90% confidence interval are plotted for PABPC1 along with its mean poly(A) length in 1-cell (n = 5 Ribo-ITP; n = 4 RNA-Seq) and 2-cell embryos. d,e,f, Pairwise correlation between protein abundance and d, RNA expression or e, Ribosome occupancy or f, Translation efficiency. Spearman correlation coefficient with Spearman’s correction is reported inside the heatmaps. g,h, Sankey diagrams depict the relationships between translation efficiency and protein abundance. The color and the thickness of the paths connecting the nodes are proportional to the correlation coefficient.