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. 2023 Feb 22;41(3):508–537. doi: 10.5534/wjmh.221027

Table 8. Recommendations – follow-up.

Follow-up on men on testosterone therapy LoE Grade
Assess the response to therapy at 3, 6 to 12 months, and every 12 months thereafter 4 C
Aim for a target level of total testosterone 15–30 nmol/L to achieve optimal response 4 C
Monitor haematocrit before treatment, at 3–6 months, 12 months and every 12 months thereafter. Decrease dosage, or switch preparation, if haematocrit >0.54. If haematocrit remains elevated, consider stopping and re-introduce at a lower dose 4 C
Assess prostate health by PSA and, ideally, DRE before commencing TRT followed by PSA at 3–6 months, 12 months and every 12 months thereafter 4 C
Assess cardiovascular risk before TRT is initiated and monitor cardiovascular risk factors throughout therapy 1b A

PSA: prostate specific antigen, DRE: digital rectal examination, TRT: testosterone replacement therapy.