Table 2.
Effect of methanolic extract of Myrica nagi (MEMN) on body weight (gm) in a high-fat diet (HFD) and GTG mouse model.
| a | ||||||
|---|---|---|---|---|---|---|
| Week | Control | Inducer (HFD) | Standard (10 mg/kg) | MEMN (100 mg/kg) | MEMN (200 mg/kg) | MEMN (400 mg/kg) |
| WK-00 | 20.83 ± 0.17 | 20.75 ± 0.20 | 20.83 ± 0.15 | 20.49 ± 0.11 | 21.98 ± 0.14 | 21.16 ± 0.12 |
| WK-08 | 22.16 ± 0.20 | 28.83 ± 0.49 | 24.86 ± 0.75 | 26.56 ± 0.21 | 25.83 ± 0.19 | 25.89 ± 0.24 |
| WK-16 | 26.66 ± 0.16 | 36.69 ± 0.30### | 22.67 ± 1.10∗∗∗ | 23.56 ± 0.52∗∗∗ | 23.83 ± 0.51∗∗∗ | 23.91 ± 0.54∗∗∗ |
| b | |||
|---|---|---|---|
| TREATMENT | WEEK 0 (Initial) | WEEK 8 (Mice observed for 8 weeks) (Final) | WEEK 16 (Mice treated for 8 weeks) (After treatment) |
| Normal Control | 18.68 ± 0.89 | 20.68 ± 0.55 | 21.00 ± 0.73 |
| Gold thioglucose (300 mg/kg) | 18.11 ± 0.85 | 30.43 ± 1.85 | 40.54 ± 1.47### |
| GTG + Orlistat (10 mg/kg) | 20.61 ± 0.34 | 30.09 ± 1.10 | 31.98 ± 0.09∗∗∗ |
| GTG + MEMN (100 mg/kg) | 20.65 ± 1.09 | 30.16 ± 0.56 | 32.78 ± 0.24∗∗∗ |
| GTG + MEMN (200 mg/kg) | 18.85 ± 1.45 | 32.16 ± 1.21 | 33.56 ± 1.19∗∗∗ |
| GTG + MEMN (400 mg/kg) | 20.92 ± 1.20 | 30.58 ± 1.21 | 33.55 ± 0.78∗∗∗ |
Methanolic extract of M. nagi., MEMN; GTG., Gold thio glucose; p.o., per oral. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ###p < 0.001, #p < 0.05, ##p < 0.01, #When compared with normal control group, ∗when compared with inducer group.