Why carry out this study?

Lebrikizumab (interleukin (IL)-13 inhibitor) has shown efficacy up to Week 52 in Phase 3 monotherapy trials (ADvocate 1 and 2) and in combination with topical corticosteroids (ADhere) for the treatment of adults and adolescents with moderate-to-severe atopic dermatitis.

This 52-week open-label study is the first to evaluate the safety and efficacy of lebrikizumab exclusively in adolescent patients (≥ 12 to < 18 years old) with moderate-to-severe atopic dermatitis.

What was learned from the study?

Lebrikizumab demonstrated a safety profile that was consistent with the established safety profile previously published and showed robust and sustained efficacy in this population with meaningful Investigator’s Global Assessment (IGA) and Eczema Area and Severity Index (EASI) responses.

This study suggests that lebrikizumab 250 mg every 2 weeks (Q2W) has positive benefit-risk and efficacy profiles in adolescent patients with moderate-to-severe atopic dermatitis up to 52 weeks of continuous treatment.