Table 2.
Associations between maternal steroid metabolites and offspring infections.
| Steroid metabolite | VDAART T1 (N = 774) 10–18 GW |
COPSAC T2 (N = 729) 22–26 GW |
VDAART T3 (N = 779) 32–38 GW |
||||||
|---|---|---|---|---|---|---|---|---|---|
| IRR (95% CI) | P-value | FDR | IRR (95% CI) | P-value | FDR | IRR (95% CI) | P-value | FDR | |
| 16a-hydroxy DHEA 3-sulfate | 1.01 (0.97,1.05) | 0.561 | 0.641 | 0.97 (0.92,1.01) | 0.157 | 0.236 | 1.04 (0.99,1.08) | 0.091 | 0.290 |
| Androstenediol (3beta,17beta) monosulfate (1) | 1.01 (0.97,1.06) | 0.530 | 0.641 | 1.04 (1,1.08) | 0.081 | 0.136 | 1.01 (0.98,1.05) | 0.570 | 0.684 |
| Androstenediol (3beta,17beta) monosulfate (2) | 1.02 (0.99,1.06) | 0.219 | 0.396 | 1.05 (1.02,1.08) | 0.002 | 0.007 | 0.98 (0.95,1.01) | 0.181 | 0.364 |
| Androstenediol (3alpha, 17alpha) monosulfate (3) | 1.04 (1.01,1.08) | 0.021 | 0.171 | 1.04 (1,1.08) | 0.064 | 0.136 | 1.05 (1.01,1.08) | 0.016 | 0.062 |
| Androstenediol (3alpha, 17alpha) monosulfate (2) | 1.05 (1.01,1.09) | 0.005 | 0.086 | 1.01 (0.98,1.04) | 0.361 | 0.451 | 1.06 (1.02,1.09) | 0.002 | 0.013 |
| Androstenediol (3beta,17beta) disulfate (2) | 1.05 (1,1.09) | 0.040 | 0.212 | 1.05 (1,1.11) | 0.076 | 0.136 | 1.03 (0.98,1.07) | 0.250 | 0.364 |
| Androstenediol (3beta,17beta) disulfate (1) | 1.03 (0.98,1.07) | 0.223 | 0.396 | 1.07 (1.03,1.12) | 0.001 | 0.005 | 1.02 (0.98,1.06) | 0.373 | 0.498 |
| 5alpha-androstan-3beta,17beta-diol disulfate | 1 (0.96,1.04) | 0.995 | 0.995 | 1.08 (1.04,1.13) | 1.21 × 10–4 | 0.001 | 1.02 (0.99,1.06) | 0.210 | 0.364 |
| 5alpha-androstan-3beta,17alpha-diol disulfate | 1.02 (1,1.05) | 0.053 | 0.213 | 1 (0.98,1.03) | 0.814 | 0.854 | 1 (0.97,1.03) | 0.971 | 0.971 |
| 5alpha-androstan-3alpha,17alpha-diol monosulfate | 1.02 (0.99,1.05) | 0.193 | 0.396 | 0.9 (0.86,0.94) | 1.06 × 10–6 | 1.59 × 10–5 | 1.01 (0.98,1.04) | 0.606 | 0.684 |
| Epiandrosterone sulfate | 1.01 (0.98,1.05) | 0.461 | 0.614 | 1.06 (1.02,1.1) | 0.004 | 0.011 | 1.02 (0.99,1.06) | 0.249 | 0.364 |
| Andro steroid monosulfate C19H28O6S (1)* | 1.01 (0.98,1.04) | 0.601 | 0.641 | 1 (0.95,1.04) | 0.854 | 0.854 | 0.99 (0.95,1.03) | 0.641 | 0.684 |
| Dehydroepiandrosterone sulfate (DHEA-S) | 1.03 (0.99,1.07) | 0.111 | 0.301 | 1.01 (0.97,1.06) | 0.557 | 0.643 | 1.03 (0.99,1.06) | 0.200 | 0.364 |
| Androsterone sulfate | 1.02 (0.98,1.06) | 0.294 | 0.471 | NA | NA | NA | 1.03 (0.99,1.06) | 0.128 | 0.342 |
| Cortisone | 1.05 (0.99,1.11) | 0.113 | 0.301 | 0.9 (0.85,0.97) | 0.002 | 0.007 | 0.9 (0.86,0.94) | 4.45 × 10–7 | 7.11 × 10–6 |
| Cortisol | 1.02 (0.97,1.09) | 0.414 | 0.602 | 0.97 (0.91,1.03) | 0.254 | 0.346 | 0.93 (0.89,0.97) | 0.002 | 0.013 |
Incidence rate ratios (IRRs), P-values, and FDR-corrected P-values of associations are shown at T1, T2, and T3 time points. Associations at P < 0.05 are bolded. Associations at 0.05 < P < 0.1 are italicized for COPSAC.