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. 2023 May 18;30(7):1710–1725. doi: 10.1038/s41418-023-01173-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Violin plots showing expression of USP28, SREBF2, HMGCS1 and FDFT1 in human Lung adenocarcinoma (ADC) and lung squamous carcinoma (SCC). Data are from TCGA (Firehose legacy). Significance was calculated using Mann–Whitney test. ^****p < 0.0001. b Tissue sections from a human NSCLC TMA were stained for USP28, SREBP2 HMGCS1 and SREBP1 by immunohistochemistry. Haematoxilin and eosin (H&E) staining is also shown. Representative images for SCC are shown. c Boxplots showing quantification of USP28, SREBP2, HMGCS and SREBP1 staining in SCC and ADC tumours. Percent positive cells are shown. (SCC: n = 33; ADC: n = 75; ^***p < 0.001, Mann-Whitney test). d Pearson correlation between expression of USP28, SREBP2 and HMGCS in SCC tumours (R = Pearson correlation coefficient, p = two tailed t-test). e Kaplan–Meier plots of overall survival of lung cancer patients (N = 1925) dichotomised into ‘high’ and ‘low’ based on median USP28 or SREBF2 expression score. Survival differences were calculated with the log-rank test.