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. 2023 May 18;30(7):1710–1725. doi: 10.1038/s41418-023-01173-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Tissue sections from KPL and KPLU lung tumours were stained for Usp28, Srebp2 and Hmgcs1 by immunohistochemistry. Haematoxylin and eosin (H&E) staining is also shown. b Boxplot showing quantification of Srebp2 staining in KPL and KPLU tumours. Percent positive cells are shown. (KPL: n = 9; KPLU: n = 7; ^***p < 0.001, Mann–Whitney test). c Tissue sections from KPL and KPLS2 tumours were stained for the adenocarcinoma marker thyroid transcription factor 1/NK2-homeobox 1 (Ttf-1/Nkx2-1), the squamous marker keratin 5 (Krt5), Srebp2 and Hmgcs1 by immunohistochemistry. H&E staining is also shown. d H&E staining of representative lung tissue sections from KPL and KPLS2 mice. e Ratio of tumour area relative to total lung area in KPL and KPLS2 mice. Data are displayed as mean ± SD (KPL: n = 11; KPLS2: n = 13; Mann-Whitney test). f Boxplot showing quantification of Srebp2 and Hmgcs1 staining in KPL and KPLS2 tumours. Percent positive nuclei or positive cells are shown. (KPL: n = 7; KPLS2: n = 9; ^***p < 0.001, Mann-Whitney test). g Tissue sections from KPL and KPLS2 tumours were stained for ΔNp63. h Boxplot showing quantification of ΔNp63 staining in KPL and KPLS2 tumours. Percent positive nuclei are shown. (KPL: n = 6; KPLS2: n = 6; ^***p < 0.05, Mann-Whitney test).