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. 2023 May 6;129(1):61–71. doi: 10.1038/s41416-023-02293-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Sum of mean Likert score change is calculated from start to end of treatment, in symptoms significantly related to tamoxifen exposure regardless of menopausal status (hot flashes, cold sweats, night sweats, vaginal discharge, and muscle cramps). P value for difference between low and high dose within each menopausal group. Symptom severity change for each of the symptoms included can be found in Supplementary Fig. 1.