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. 2023 May 6;129(1):61–71. doi: 10.1038/s41416-023-02293-z

Table 1.

Baseline characteristics and adherence to treatment of the included 1175 women, stratified by tamoxifen dose.

Tamoxifen dose in mg
Characteristic All 0 1 2.5 5 10 20
Number of women 1175 202 193 194 188 199 199
Mean age at baseline, years (SD) 55.7 (9.7) 56.4 (9.7) 54.5 (9.5) 55.3 (9.9) 55.5 (9.9) 56.5 (10.0) 55.9 (9.3)
Number of premenopausal women (%) 454 (38.6) 70 (34.7) 81 (42.0) 76 (39.2) 72 (38.3) 76 (38.2) 79 (39.7)
Number of postmenopausal women (%) 721 (61.4) 132 (65.3) 112 (58.0) 118 (60.8) 116 (61.7) 123 (61.8) 120 (60.3)
Mean age at menopause, years (SD) 50.0 (5.12) 50.0 (4.78) 50.0 (5.11) 50.3 (5.66) 49.6 (5.69) 49.3 (4.61) 50.4 (4.97)
Mean age at menarche, years (SD) 13.0 (1.36) 13.2 (1.40) 13.0 (1.39) 12.8 (1.37) 13.0 (1.32) 13.1 (1.37) 12.9 (1.32)
Mean BMI (SD) 25.4 (3.8) 25.0 (3.6) 25.5 (3.8) 25.8 (4.3) 25.6 (3.9) 25.4 (3.7) 25.4 (3.3)
Mean number of pregnancies (SD) 2.6 (1.6) 2.5 (1.4) 2.6 (1.6) 2.8 (1.6) 2.4 (1.6) 2.5 (1.5) 2.6 (1.7)
Mean age at first birth, years (SD) 28.8 (5.4) 28.7 (5.5) 28.8 (5.3) 29.0 (5.3) 28.7 (5.5) 28.8 (5.5) 28.9 (5.5)
Number of current smokers (%) 135 (12) 17 (8) 22 (11) 18 (9) 19 (10) 26 (13) 33 (17)
Mean gram/week of alcohol last year (SD) 49.4 (61.4) 53.6 (64.7) 48.9 (59.1) 43.3 (43.9) 49.4 (60.8) 53.7 (81.8) 47.5 (51.6)
Adherence
Compliant to treatmenta (%)
  All 996 (85.3) 182 (90.1) 170 (88.5) 159 (82.0) 152 (82.2) 164 (83.2) 169 (85.8)
  Premenopausal 393 (87.1) 62 (88.6) 71 (87.7) 64 (84.2) 64 (91.4) 65 (85.5) 67 (85.9)
  Postmenopausal 603 (84.2) 120 (90.9) 99 (89.2) 95 (80.5) 88 (76.5) 99 (81.8) 102 (85.7)
Number of women that discontinued treatment due to side effects (%)
  All 132 (11.2) 13 (6.4) 15 (7.8) 28 (14.4) 27 (14.4) 27 (13.6) 22 (11.1)
  Premenopausal 35 (7.7) 4 (5.7) 6 (7.4) 6 (7.9) 5 (6.9) 7 (9.2) 7 (8.9)
  Postmenopausal 97 (13.5) 9 (6.8) 9 (8.0) 22 (18.6) 22 (19.0) 20 (16.3) 15 (12.5)

BMI body mass index, SD standard deviation.

aCompliant to treatment: defined per protocol as 80 % of tablets taken. Missing information for 8 participants (3 premenopausal, 5 postmenopausal).