Table 1.
Clinico-biological features of RGAneg B-ALL cases, including BCR::ABL1-like and non-BCR::ABL1-like ALL cases.
| Parameters | RGAneg B-ALL cases (n = 108) | non-BCR::ABL1-like ALLs (n = 71) | BCR::ABL1-like ALLs (n = 37) | Sig. |
|---|---|---|---|---|
| Age | 108 | 65.74% (71/108) | 34.25% (37/108) | ns |
| Median | 20 | 21 | 18 | |
| Range (min–max) | 12–62 | 12–61 | 12–62 | |
| Sex | ||||
| Male | 68.51% (74/108) | 69.01% (49/71) | 67.56% (25/37) | ns |
| Median (age) | 19 | 20 | 18 | |
| Range | 12–62 | 13–50 | 12–62 | |
| Females | 31.48% (34/108) | 30.98% (22/71) | 32.43% (12/37) | ns |
| Median (age) | 28 | 34.50 | 21.5 | |
| Range | 13–61 | 13–61 | 14–47 | |
| H.B. g/dl | ns | |||
| Median | 6.85 | 7.2 | 6.5 | |
| Range (min–max) | 2.4–13.4 | 3.3–9.3 | 2.4–13.4 | |
| PLT × 109/l | ns | |||
| Median | 23.5 | 23 | 24 | |
| Range (min–max) | 4–324 | 4–324 | 5–287 | |
| TLC × 109/l | 0.018* | |||
| Median | 14.5 | 12.4 | 16.60 | |
| Range (min–max) | 0.6–317.5 | 0.7–156 | 0.6–317.5 | |
| Blasts n (%) | 86.5 (25–98) | 85 (27–98) | 88 (25–97) | ns |
| M.R.D. positivity/induction failure | 80.55% (87/108) | 19.29% (11/57) | 40% (12/30) | 0.83 |
| IKZF1 (Δ 4–7 exon deletion) | 8.33% (9/108) | 2.81% (2/71) | 18.91% (7/37) | ns |
| BCR::ABL1-like ALL cases | ||||
| Negative | Positive | |||
| CGFs in BCR-ABL1-like ALL cases | 70.27% (26/37) | 65.38% (17/26) | 34.61% (9/26) | |
| TSLPR/CRLF2 Positivity | 70.27% (n = 26/37) | 88.46% (23/26) | 11.53% (3/26) | |
HB haemoglobin, TLC total leucocyte count.
*Statistical significant.
Normally distributed Data: Student’s t test, non-normally distributed data: Mann–Whitney test.