Table 3.
Reported incidence comparison of IKZF1 deletions, including IKZF1 (Δ4–7) deletion in B-ALLs, RGAneg B-ALL cases & BCR::ABL1-like ALL cases.
| Authors [Ref.] | Method | IKZF1& IKZF1 (Δ4–7) deletion. | Cases |
|---|---|---|---|
| Mullighan CG et al. [29] | 250k Sty and Nsp SNP array | 83.7% (14/23) IKZF1 deletion. | BCR::ABL1-positive ALLs |
| Mullighan CG et al. [3] | 250k Sty and Nsp SNP array | 28.50% (63/221) IKZF1 deletion | High-risk B-ALLs |
| Iacobucci I et al. [51] | 250k Sty and Nsp SNP array | 42% IKZF1(Δ4–7) | BCR::ABL1-positive ALLs |
| Kuiper RP et al. [53] | MLPA | 13.7% (18/31) IKZF1 deletion | Paediatric B-ALLs |
| Iacobucci I et al. [52] | 250k Sty and Nsp SNP array | 49% IKZF1(Δ4–7) | BCR::ABL1-positive ALLs |
| Yamashita Y et al. [54] | MLPA | 12% (22/177) IKZF1 deletion | BCR::ABL1-negative ALLs |
| Martinelli G et al. [55] | 250k Sty and Nsp SNP array | 63% (52/83) IKZF1 deletion | BCR::ABL1-positive ALLs |
| Caye A et al. [56] |
MLPA PCR |
4.49% (23/512) IKZF1(Δ4–7) 6.64% (34/512) IKZF1(Δ4–7) |
BCR::ABL1-negative ALLs |
| MI JQ et al. [57] | 250k Sty and Nsp SNP array |
14.7%) (56/607) IKZF1(Δ4–7) 31.3% (64/262)) IKZF1(Δ4–7) |
Paediatric B-ALLs Adult B-ALLs |
| Palmi C et al. [58] | MLPA |
13.2% (54/410) deletion. 2.19% (9/410) IKZF1 (Δ4–7). |
BCP-ALL cases |
| Liu X et al. [59] | MLPA |
20% (19/96) IKZF1 deletion 21.05% (4/19) IKZF1 (Δ4–7) deletion. |
B-ALL cases |
| Asai D et al. [60] | MLPA | 9.4% (19/202) IKZF1 deletion | B-ALL cases |
| Hashiguchi J et al. [49] | DD-PCR | 12% (22/177) IKZF1 deletion | BCP-ALL cases |
| Chiaretti S et al. [22] | MLPA | 63.96% (14/22) IKZF1 deletion | BCR::ABL1-like ALL cases |
| Present study | DD-PCR | 8.33% (9/108) IKZF1 (Δ4–7) deletion 18.91% (7/37) IKZF1 (Δ4–7) deletions |
RGAneg B-ALL cases BCR::ABL1-like ALL cases |