Table 1.
Network enrichment analysis results from metabolites in unilateral ureteral obstruction.
| Total | Expected | Hits | Raw P value | Impact | |
|---|---|---|---|---|---|
| Arginine and proline metabolism | 38 | 0.65604 | 6 | 2.74E-05 | 0.41283 |
| Arginine biosynthesis | 14 | 0.2417 | 4 | 6.23E-05 | 0.36548 |
| Pentose phosphate pathway | 22 | 0.37981 | 4 | 0.000414 | 0.25044 |
| Alanine, aspartate and glutamate metabolism | 28 | 0.4384 | 4 | 0.00108 | 0.08654 |
| Glutathione metabolism | 28 | 0.4384 | 3 | 0.011244 | 0.01438 |
| Fructose and mannose metabolism | 18 | 0.31076 | 2 | 0.037018 | 0.05452 |
| Citrate cycle (TCA cycle) | 20 | 0.34529 | 2 | 0.045012 | 0.14041 |
| Phenylalanine, tyrosine and tryptophan biosynthesis | 4 | 0.069057 | 1 | 0.067355 | 0.5 |
| Glycolysis/gluconeogenesis | 26 | 0.44887 | 2 | 0.072294 | 0.07202 |
| Purine metabolism | 66 | 1.1394 | 3 | 0.10193 | 0.0389 |
| Glyoxylate and dicarboxylate metabolism | 32 | 0.55246 | 2 | 0.10364 | 0.05556 |
| Pyrimidine metabolism | 39 | 0.67331 | 2 | 0.14399 | 0.0256 |
| Phenylalanine metabolism | 12 | 0.20717 | 1 | 0.18922 | 0.35714 |
| Butanoate metabolism | 15 | 0.25896 | 1 | 0.23084 | 0.03175 |
| Starch and sucrose metabolism | 15 | 0.25896 | 1 | 0.23084 | 0.02703 |
| Glycerophospholipid metabolism | 36 | 0.62151 | 1 | 0.46975 | 0.01896 |
| Tryptophan metabolism | 41 | 0.70784 | 1 | 0.51507 | 0.14305 |
UUO unilateral ureteral obstruction, TCA cycle tricarboxylic acid cycle.
Network analysis was performed by focusing on metabolites that were increased above 1.0 in the UUO/sham ratio and had a P value of ≤0.05 with the Kyoto Encyclopedia of Genes and Genomes database.