Table 1.
Baseline characteristics.
| Variable | Total N = 747 (%) |
|---|---|
| Sex M/F | 456 (61.0)/291 (39.0) |
| Age | |
| median | 71 years (range 32–95) |
| <65/65–69/≥70 years | 215 (28.8)/132 (17.7)/400 (53.5) |
| Median time from diagnosis months (IQ range) | 11 (2–39) |
| ECOG performance status 0/1/≥2 | 421 (56.4) / 275 (36.8)/51 (6.8) |
| Rai stage 0/I/II/III/IV | 45 (6.0)/159 (21.3)/206 (27.6)/195 (26.1)/142 (19.0) |
| Bulky and/or elevated lymphocytosis and/or severe splenomegaly yes/no | 546 (73.1)/201 (26.9) |
| del 17p absent/present/not available | 134 (18.0)/568 (76.0)/45 (6.0) |
| TP53 WT/mutated /not available | 112 (15.0)/429 (57.4)/206 (27.6) |
| del 17p only / TP53 mut only /del 17p & TP53 muta | 112 (15.0)/134 (17.9)/250 (33.4) |
| History of atrial fibrillation yes/no | 25 (3.4)/722 (96.6) |
| Pre-existing severe heart disease yes/no | 21 (2.8)/726 (97.2) |
| Renal impairment (Creatine clearance < 70 ml/min) yes/no | 68 (9.1)/679 (90.9) |
| Concomitant use of anticoagulant yes/no | 30 (4.0)/717 (96.0) |
| Number of experienced/less experienced centersb | 24 (15.3)/133 (84.7) |
| Patients treated at experienced/less experienced centers | 312 (41.8)/435 (58.2) |
a206 patients have reported del(17)p with no information on the presence/absence of TP53; 46 patients have TP53 with no cytogenetic analysis performed/reported. These patients are not included in the reported frequencies.
bCenters with at least 2 years of experience in the wMRS.