Table 3.

Multivariate analysis for TTD and OS.

	HR (95% CI)
TTD variable
Age years <65/65–69/≥70
65–69 vs <65 years	1.16 (0.83–1.61)
≥70 vs <65 years	1.82 (1.41–2.35)
ECOG performance status 0/1/≥2
1 vs 0	1.32 (1.07–1.63)
2+ vs 1	1.94 (1.35–2.77)
History of atrial fibrillation yes/no	1.80 (1.14–2.85)
Pre-existing severe heart disease yes/no	1.69 (1.03–2.77)
Renal impairmenta no vs yes	0.72 (0.52–0.99)
OS variable
Gender M vs F	1.38 (1.01–1.87)
Age years <65/65–69/>70
65-69 vs <65 years	1.30 (0.81–2.09)
≥70 vs <65 years	1.68 (1.15–2.45)
ECOG performance status 0/1/≥2
1 vs 0	1.43 (1.05–1.95)
2+ vs 1	2.59 (1.63–4.12)
Pre-existing severe heart disease yes/no	1.77 (0.89–3.50)
Renal impairmenta no vs yes	0.72 (0.46–1.13)

^aCreatine clearance < 70 ml/min.