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. 2023 Jun 28;14:3830. doi: 10.1038/s41467-023-39528-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A AZD7762 combinations: top combinations sorted by median score across cell lines using Higher than Single Agent metric. B Pattern of HSA events across top combinatorial partners for AZD7762 across cell lines. Each row corresponds to the specified drug combined with AZD7762 and each column (mark) corresponds to a cell line. Colored marks correspond to positive HSA events. The cell lines are in the same order across rows revealing differential pattern of HSA events for different combinations. C Top combinations (with AZD7762) based on median synergy across cell lines. D Pattern of synergistic events displayed as in (B) but using synergy rather than HSA.