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. 2023 Jun 28;14:3830. doi: 10.1038/s41467-023-39528-9

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — A–C The pattern of synergies for a given drug is presented as a ranked ordered plot of synergy scores for the first listed drug (top) compared to the synergy score of related drugs with cell lines in the same order as for the first drug. The log of the synergy score is plotted. A Anchor drug is trametinib (MEK1/2) B Anchor drug is vorinostat (HDAC); C Anchor drug is OSI-027 (MTORC1/2). D Overview of differential pattern for related library drugs across anchors. Selected library drugs with similar targets were chosen (rows) and the number of synergies in combination with the indicated anchors (columns) are plotted as bars (the bar size is proportional to percent of the synergy scores that are within the top 5% of all synergy scores).