Table 1.
Author/year | Design/country | Exclusion of the urate-lowering drugs | Duration (weeks) | Total sample size/population | Baseline characteristics of interventional group | Dietary facts | Changes in UA; DASH vs control6 (mg/dL, 95% CI) | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
Gender, female (%) | Age, Mean (y) | HTN (%) | High baseline UA (%) | Intervention | Control | ||||||
Tang et al.27 | RCT/USA | N/A | 12 | 103/Adults with pre- or stage 1 HTN | 62.7 | 49.9 | 29.4 | 6.61 | DASH5 diet | Typical isocaloric American diet | − 0.40 (− 0.79, − 0.01) |
Juraschek et al.28 | RCT/USA | No | 8 | 117/Adult African-Americans with controlled HTN | 65 | 59.2 | 100 | 302 | DASH-plus diet: coach-directed, 30$/week allowance limited to high K foods (fruits, vegetables, nuts, or dried beans) | A DASH brochure & 30$/week allowance | − 0.01 (− 0.39, 0.38) |
Juraschek et al.29 | RCT/USA | Yes | 4 | 43/Adults with gout (self-reported) & a UA concentration > 7 mg/dL | 18 | 42.5 | 50 | 1003 | DASH diet with 105$/week allowance of dietitian-directed groceries | self-directed grocery shopping with 15$/day allowance | − 0.51 (− 1.16, 0.13) |
Juraschek et al.7 | RCT/USA | No | 8 | 327/Adults with pre- or stage 1 HTN | 52.7 | 44.8 | 24.5 | 23.04 | DASH diet with K, Mg & Ca at the 75th percentile levels of U.S. consumption, and high in fiber and protein | K, Mg, and Ca levels matching the 25th percentile of U.S. consumption, & macronutrient and fiber at the average intake levels in the U.S | − 0.25 (− 0.43, − 0.08) |
RCT: Randomized Control Trial, HTN: Hypertension, UA: Uric Acid, DASH: Dietary Approaches to Stop Hypertension, CI: Confidence Interval, K: potassium, Mg: magnesium, Ca: calcium.
1UA ≥ 6 mg/dl.
2UA > 7 mg/dl.
3UA ≥ 7 mg/dl.
4UA > 6 mg/dl for women or > 7 mg/dl for men.
5All mentioned DASH diets consist of fruits, vegetables, and low-fat dairy foods and reduced consumption of saturated fat, total fat, and cholesterol along with whole grains, poultry, fish, and nuts and restricted red meat, sweets, and sugar-containing beverages.
6As mentioned in the articles.