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. 2023 Jun 28;13:10486. doi: 10.1038/s41598-023-37577-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cerebral blood volume (CBV) values within 24 h after insult. At the end of the insult, CBV values increased in all four groups, followed by a decreasing trend for the NT, TH, and H₂-TH until 12 h after insult. However, the CBV values of the H₂-TH group rose from 12 to 24 h after insult. CBV in the H₂ group showed a relatively stable trend and the values increased between 12 and 24 h. At 24 h after insult, the CBV values of both the H₂-TH and H₂ groups were significantly higher than those in the NT and TH groups. The values are expressed as the mean (SD).