Table 1.
Physiological parameters at baseline, 0 h (end of insult), 1 h, 6 h, 12 h, and 24 h after the insult.
| Parameters | Baseline | 0 h | 1 h | 6 h | 12 h | 24 h |
|---|---|---|---|---|---|---|
| HR (bpm) | ||||||
| NT | 212.7 ± 22.9 | 150.7 ± 17.4*** | 223.1 ± 21.5 | 228.1 ± 19.6§ | 235.1 ± 16.4§ | 195.1 ± 36.7 |
| H2 | 179.7 ± 14.9 | 140.4 ± 32.7* | 207.9 ± 15.3 | 230.1 ± 28.7**,§ | 217.1 ± 17.1§ | 183.4 ± 31.8 |
| TH | 211.2 ± 47.0 | 175.2 ± 48.2 | 207.0 ± 38.9 | 213.3 ± 8.1 | 235.1 ± 16.4 | 195.1 ± 36.7 |
| H2-TH | 215.0 ± 11.1 | 166.8 ± 17.1** | 239.7 ± 18.2 | 179.0 ± 19.9* | 172.7 ± 30.0* | 177.3 ± 23.1* |
| MABP (mmHg) | ||||||
| NT | 79.6 ± 6.5 | 48.6 ± 12.7**** | 64.0 ± 6.7* | 72.0 ± 11.3 | 67.1 ± 12.6 | 61.0 ± 9.8* |
| H2 | 72.7 ± 6.3 | 45.6 ± 11.1*** | 66.4 ± 8.3 | 69.4 ± 6.7 | 66.9 ± 9.2 | 55.4 ± 3.8** |
| TH | 75.3 ± 15.9 | 50.8 ± 10.7** | 76.2 ± 6.7 | 66.8 ± 3.5 | 68.3 ± 8.2 | 59.7 ± 7.0 |
| H2-TH | 76.2 ± 4.1 | 49.4 ± 15.3*** | 68.3 ± 2.9 | 71.7 ± 8.5 | 64.5 ± 7.8 | 63.5 ± 3.6 |
| RT (°C) | ||||||
| NT | 37.5 ± 0.7 | 37.6 ± 0.5 | 38.2 ± 0.6#,§ | 38.4 ± 0.4*,#,§ | 38.0 ± 0.4#,§ | 38.3 ± 0.6#,§ |
| H2 | 38.2 ± 0.3 | 38.1 ± 0.3# | 38.2 ± 0.4#,§ | 38.3 ± 0.3#,§ | 38.4 ± 0.5#,§ | 38.8 ± 0.2*,#,§ |
| TH | 36.8 ± 0.8 | 36.8 ± 0.8 | 33.9 ± 0.8****,§ | 33.9 ± 0.3**** | 34.0 ± 0.4****,§ | 34.1 ± 0.4****,§ |
| H2-TH | 38.1 ± 0.8 | 37.6 ± 1.0 | 36.4 ± 1.1 | 33.4 ± 0.6**** | 32.9 ± 1.0**** | 35.3 ± 1.6** |
Values are expressed as the mean ± SD. NT normothermia, TH therapeutic hypothermia, H2 hydrogen ventilation, TH-H2 therapeutic hypothermia with hydrogen ventilation. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 versus baseline; #p < 0.05 versus TH; §p < 0.05 versus H2-TH; †p < 0.05 versus H2.