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. 2023 Jun 7;30(7):1786–1798. doi: 10.1038/s41418-023-01179-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Representative western blots showing the expression of TMEM11 in the nucleus, cytoplasm and mitochondria of cardiomyocytes (n = 3 independent experiments). b Representative western blots showing the expression of TMEM11 in hearts at different ages of mice (n = 4 mice). c Representative western blots showing the expression of TMEM11 in the nucleus, cytoplasm and mitochondria of cardiomyocytes (n = 3 mice). d–h Neonatal mice cardiomyocytes were infected with adenovirus harboring TMEM11-shRNA or its control (TMEM11-shNC) for 48 h. d The expression levels of TMEM11 mRNA assessed by immunoblot (n = 3 independent experiments). e Representative confocal images of Ki67-positive cardiomyocytes (Bar = 20 μm) and quantification of Ki67-positive (right) cells (n = 6 independent experiments). f Representative confocal images of pH3-positive cardiomyocytes and quantification of pH3-positive cells in TMEM11-shNC and TMEM11-shRNA infected cardiomyocytes (Bar = 20 μm) (n = 6 independent experiments). Representative confocal images of Aurora-B-positive cardiomyocytes (g) and quantification (h) of Aurora-B-positive cells in TMEM11-shNC and TMEM11-shRNA infected cardiomyocytes (Bar = 20 μm) (n = 6 independent experiments). i, j Neonatal mice cardiomyocytes were infected with adenovirus harboring negative control (Vector) or mouse TMEM11 gene (TMEM11) for 48 h. i Representative western blots showing the expression of TMEM11 (n = 4 independent experiment). j PH3-positive cardiomyocytes were measured in Vector and TMEM11 treated cardiomyocytes (n = 6 independent experiment). Data are presented as the mean ± s.d. Two-sided Student’s t test (e, f, h and j) was performed.