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. 2023 Jun 7;30(7):1786–1798. doi: 10.1038/s41418-023-01179-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Western blot image (top) and statistical data (bottom) showing the myocardial level of TMEM11 in wild type (WT) and TMEM11 KO adult mice hearts (n = 8 mice). b–h TMEM11 silencing increases cardiomyocytes proliferation in adult mice hearts. Representative images of gross morphology and haematoxylin-eosin stained transverse sections of hearts from WT and TMEM11 KO mice (Bar = 2 mm) (b). Heart to body weight ratio (c) and echocardiography analysis of fractional shortening (FS) (d) in WT and TMEM11 KO mice (n = 7 mice). e Representative confocal images of Ki67-positive cardiomyocytes (red, Bar = 25 μm) and quantification of Ki67-positive (right) cells (n = 7 mice per group). cTNT (green) mark cardiomyocytes and DAPI (blue) labels nuclei. f, g Representative confocal images and qualification of pH3-positive cardiomyocytes (red, Bar = 25 μm) in WT and TMEM11 KO hearts. h Aurora-B-positive (red) cardiomyocytes was calculated in WT and TMEM11 KO hearts. cTNT marks cardiomyocytes and DAPI labels nuclei (Bar = 25 μm). (n = 6 mice per group). Data are presented as the mean ± s.d. Two-sided Student’s t test (a, c–e, g and h) was performed.