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. 2023 May 20;30(7):1771–1785. doi: 10.1038/s41418-023-01178-1

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — A–D HCT116 cells with the indicated genotypes were exposed to curcumin (15 μM), 5-FU (2 mg/L), or curcumin combined with 5-FU. After 48 hours cell viability was determined by MTT assays. E, F The viability of HCEC-1CT and CCD-18Co cells was determined by MTT assay after the indicated treatments for 48 hours. G. Schematic model of the findings obtained in this study.